Hypoxia-Activated Prodrug Synthesis

Phenylacetic acid (99.0%), zinc chloride (98.0%), phthalimide (98.0%), zinc phenylacetate (98.0%), α, ω-amino-terminated polyethylene glycol (PEG, Mw = 2 kDa, 99.5%), chloro (1,5-cyclooctadiene) iridium(I) dimer ([Ir(COD)₂Cl₂]₂, 95.0%) and chlorosulphonic acid (97.0%)were obtained from J & K Chemical Ltd. Tirapazamine (TPZ), AQ4N, PR104, TH302 and solvents were purchased from Sigma-Aldrich Chemical Co. All the commercially available reagents were used as received without any further purification. The cell culture products were purchased from Thermo Fisher Scientific unless otherwise stated.

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Ge L., Tang Y., Wang C., Chen J., Mao H, & Jiang X. (2024). A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement. Nature Communications, 15, 153.

Publication 2024

Corresponding Organization :

Other organizations : Nanjing University, Emory University

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Variable analysis

independent variables

Phenylacetic acid (99.0%)
Zinc chloride (98.0%)
Phthalimide (98.0%)
Zinc phenylacetate (98.0%)
α, ω-amino-terminated polyethylene glycol (PEG, Mw = 2 kDa, 99.5%)
Chloro (1,5-cyclooctadiene) iridium(I) dimer ([Ir(COD)2Cl2]2, 95.0%)
Chlorosulphonic acid (97.0%)
Tirapazamine (TPZ)
PR104
TH302
Solvents

dependent variables

Not explicitly mentioned

control variables

Not explicitly mentioned

controls

No positive or negative controls were explicitly mentioned.

Annotations

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