Colorectal Cancer Genetics Study in Scotland

Main analyses were replicated using the Study of Colorectal Cancer in Scotland (SOCCS), a population-based case-control study conducted between 1996 and 2006. Details of study recruitment and data collection have been previously described in detail (19 (link)). The study included 1,556 incident CRC cases, and 2,201 adult cancer-free controls, identified from the Community Health Index in Scotland. Genotyping was conducted using custom Illumina Infinium arrays and OmniExpressExome BeadChip arrays. Detailed descriptions of genotyping and imputation of common genetic variants are presented in previous reports (20 (link),21 (link)). The study was approved by the Multicenter Research Ethics Committee for Scotland (reference number: 01/0/05) and by the Research and Development Office of NHS Lothian (reference number: 2003/W/GEN/05).

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Weigl K., Hsu L., Knebel P., Hoffmeister M., Timofeeva M., Farrington S., Dunlop M, & Brenner H. (2019). Head-to-Head Comparison of Family History of Colorectal Cancer and a Genetic Risk Score for Colorectal Cancer Risk Stratification. Clinical and Translational Gastroenterology, 10(12), e00106.

Publication 2019

Infinium arrays

Adult Cancer Genetic variants Research ethics committee

Corresponding Organization : University Hospital Heidelberg

Other organizations : Fred Hutch Cancer Center, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, National Center for Tumor Diseases

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Colorectal cancer (CRC) incidence

control variables

Adult cancer-free controls identified from the Community Health Index in Scotland

controls

Positive control: None mentioned
Negative control: None mentioned

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