All patients are assessed with a ~ 1-h neuropsychological test battery, including ‘cold’ (emotion-independent) cognitive tasks indexing reaction time; psychomotor speed; verbal learning and memory; working memory; and executive functions, as well as ‘hot’ (emotion-dependent) cognitive tasks from the Danish version of the EMOTICOM test-battery indexing emotion recognition; emotion detection; and moral emotions in social situations [60 (link)].
Patients in subcohorts I-II will complete an additional ~ 1 h of testing with tasks assessing mental flexibility, verbal fluency, and visuospatial learning and memory (see Additional questionnaires for the subcohort I-II only are in bold.
Table 3 for a complete overview of all cognitive tasks). In addition, patients’ subjective experiences of cognitive disturbances will be assessed by the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) questionnaire [36 (link)].

Cognitive testing before treatment

Cognitive TestCognitive Domaine
Whole Cohort
 Simple Reaction Time task (SRT)Reaction time
 Trail Making Test A & BPsychomotor speed/executive function
 Symbol Digit Modality Task (SDMT)Psychomotor speed/working memory
 Letter-Number Sequence (LNS)Working memory
 D-KEFS Color-Word Interference Test (Stroop)Executive function
 Rey Auditory Verbal Learning Test (RAVLT)Learning/memory
 EMOTICOM Emotional Recognition Task (ERT)Emotion recognition accuracy
 EMOTICOM Emotional Intensity Morphing Task (IMT)Emotion perceptual detection threshold
 EMOITCOM Moral Emotions Task (MET)Social cognition: guilt and shame
Additional testing in the subcohorts
 D-KEFS Verbal FluencyExecutive function
 Rey Complex Figure Test (RCFT)Visuo-spatial learning/memory
 Probabilistic Reversal Learning taskLearning within a feedback context
 Screen for Cognitive Impairments in Psychiatry—Depression (SCIP-D)Memory, working memory, vocabulary, psychomotor speed
Patients in subcohorts I-II will complete an additional ~ 1 h of testing with tasks assessing mental flexibility, verbal fluency, and visuospatial learning and memory (see Additional questionnaires for the subcohort I-II only are in bold.
Free full text: Click here