WZ4002, AZD9291 and CO-1686 were synthesized using previously published methods (14 (link)–16 ). Gefitinib, Afatinib, Neratinib, CL-387,785 were obtained from Selleck chemicals. The synthesis of TX2-30 is described in supplementary methods . Stock solutions of all drugs were prepared in DMSO and stored at −80°C.
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Synthesis and Acquisition of EGFR Inhibitors
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Corresponding Organization : Harvard University
Other organizations : Peking University
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Variable analysis
independent variables
- WZ4002
- AZD9291
- CO-1686
- Gefitinib
- Afatinib
- Neratinib
- CL-387,785
- TX2-30
- Not explicitly mentioned
- DMSO was used as a solvent for stock solutions of all drugs
- Positive control: Not specified
- Negative control: Not specified
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