All subjects avoided adenosine antagonizers (e.g. caffeine) for ≥24 h before CMR. T1-mapping was performed using the Shortened Modified Look-Locker Inversion recovery (ShMOLLI) prototype sequence (WIP 561 and 448C) with inline map generation, which uses 9-heartbeats breath-holds per T1-map acquisition and enables on-screen image reconstruction within 10 s [14 (link)].
Native T1-maps were acquired at rest and during peak adenosine stress (140 μg/kg/min, 4 min, IV) in short-axis (basal, mid-ventricular, apical) slices, followed immediately by first-pass perfusion imaging on matching slices during peak stress, with an IV bolus of GBCA (0.03 mmol/kg at 6 ml/s; Dotarem, Guerbet, Villepinte, France) and saline flush (15 ml at 6 ml/s) [15 (link), 16 (link)]. Matching rest perfusion images were acquired >15 min after stress perfusion and adenosine discontinuation to allow sufficient time for contrast washout [15 (link), 16 (link)].
Native T1-maps were acquired at rest and during peak adenosine stress (140 μg/kg/min, 4 min, IV) in short-axis (basal, mid-ventricular, apical) slices, followed immediately by first-pass perfusion imaging on matching slices during peak stress, with an IV bolus of GBCA (0.03 mmol/kg at 6 ml/s; Dotarem, Guerbet, Villepinte, France) and saline flush (15 ml at 6 ml/s) [15 (link), 16 (link)]. Matching rest perfusion images were acquired >15 min after stress perfusion and adenosine discontinuation to allow sufficient time for contrast washout [15 (link), 16 (link)].
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