Fasting Biomarker Measurement Protocol

Fasting venous blood was collected from each fasting patient participating in the biomarker substudy within 24±12 hours after randomization. Blood samples were collected by face-to-face interviews at each center and delivered through cold-chain to Beijing Tiantan Hospital and stored at −80° C. GA assay was centrally measured with a specific equipment (catalog number 4085-717; Ruiyuan Bio-Technique Co.Ltd., Ningbo, China) through a Roche Modular P800 system. We used the percentage of total serum albumin to express the levels of GA. [38 (link), 39 (link)] Hs-CRP was measured through a turbidimetric immunoassay (Ji’en Technique Co Ltd, Shanghai, China) on a Roche Modular P800 system (Roche, Basel, Switzerland). [31 (link)] All measurements were centrally conducted by laboratory technicians who were not informed of study assignments and clinical outcomes of patients.

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Guo Y., Wang G., Jing J., Wang A., Zhang X., Meng X., Zhao X., Liu L., Li H., Wang D., Wang Y, & Wang Y. (2021). Stress hyperglycemia may have higher risk of stroke recurrence than previously diagnosed diabetes mellitus. Aging (Albany NY), 13(6), 9108-9118.

Publication 2021

Roche Modular P800 system

Assay Biomarker Blood Face Hs crp Laboratory technicians Patients Serum albumin Turbidimetric immunoassay Venous blood

Corresponding Organization :

Other organizations : Beijing Tian Tan Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Chinese Institute for Brain Research, Inner Mongolia Medical University, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center

Top 5 similar protocols

Variable analysis

independent variables

Randomization

dependent variables

Glycated albumin (GA) levels
High-sensitivity C-reactive protein (hs-CRP) levels

control variables

Fasting venous blood collection within 24±12 hours after randomization
Blood samples collected by face-to-face interviews at each center and delivered through cold-chain to Beijing Tiantan Hospital
Blood samples stored at −80° C
GA assay centrally measured with a specific equipment (catalog number 4085-717; Ruiyuan Bio-Technique Co.Ltd., Ningbo, China) through a Roche Modular P800 system
Hs-CRP measured through a turbidimetric immunoassay (Ji'en Technique Co Ltd, Shanghai, China) on a Roche Modular P800 system (Roche, Basel, Switzerland)
All measurements centrally conducted by laboratory technicians who were not informed of study assignments and clinical outcomes of patients

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