Identifying Psoriasis Drug Candidates via Connectivity Map

To investigate the candidate drugs for different subtypes of psoriasis, Connectivity Map analysis was performed (https://clue.io/). The Connectivity Map is a pharmacogenome-based tool, which is conducted to explore the potential candidates targeting immunophenotype-related biological pathways and genes as well as understanding the potential MoAs of drugs [17 ]. To be specific, 300 genes containing top 150 up-regulated genes and top 150 down-regulated genes were obtained from difference analysis between C1 and C2 subtypes of psoriasis. Then, these 300 genes were used in the analysis of Connectivity Map.

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Li Y., Li L., Tian Y., Luo J., Huang J., Zhang L., Zhang J., Li X, & Hu L. (2023). Identification of novel immune subtypes and potential hub genes of patients with psoriasis. Journal of Translational Medicine, 21, 182.

Publication 2023

Biological Down Drugs Genes Immunophenotype Psoriasis

Corresponding Organization :

Other organizations : Tianjin Medical University, Tianjin University of Traditional Chinese Medicine, Tianjin Medical University General Hospital

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Variable analysis

independent variables

Connectivity Map analysis

dependent variables

Potential candidates targeting immunophenotype-related biological pathways and genes
Potential MoAs of drugs

control variables

Control variables not explicitly mentioned

controls

No positive or negative controls were specified by the authors

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