Structural Modeling of SMARCE1 Variants

Three-dimensional structural models of wild-type and mutant SMARCE1 were predicted based on the whole sequence using AlphaFold2 v2.0.0 in casp14 mode [81 (link)]. Pairwise TM-scores of the predicted tertiary structures were calculated with TM-align [82 (link), 83 (link)], with the mutant protein of SMARCE1 compared against that of the wild-type using Student’s t test to determine whether variation in conformation existed between the models. Structures with a TM-score > 0.5 assume generally the same fold.

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Tang C.Y., Zhang X., Xu X., Sun S., Peng C., Song M.H., Yan C., Sun H., Liu M., Xie L., Luo S.J, & Li J.T. (2023). Genetic mapping and molecular mechanism behind color variation in the Asian vine snake. Genome Biology, 24, 46.

Publication 2023

Based sequence Mutant protein Smarce1 Student

Corresponding Organization :

Other organizations : Chengdu Institute of Biology, Chinese Academy of Sciences, Sichuan University, Peking University, University of Chinese Academy of Sciences

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Variable analysis

independent variables

Mutation in the SMARCE1 protein

dependent variables

Conformation (tertiary structure) of the wild-type and mutant SMARCE1 protein

control variables

Whole sequence of the SMARCE1 protein

positive controls

Not specified

negative controls

Not specified

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