Combination Therapy for LVAD Driveline Infection

Example 4

The patient received an artificial heart (LVAD) in 2013. From fall 2015, he was initially in outpatient treatment for driveline infection. The first documented driveline treatment with ActiMaris took Place®. A few months later, inpatient admission was required for operative remediation of the infection. The finding was so pronounced that odor of the Pseudomonas infestation could be detected before the patient entered through the door. The degree of infection is shown in FIGS. 1A and 1B. Operative revision was carried out immediately. After the bleeding tendency subsided, the patient was treated with the combination method according to the invention. The infection parameters normalized within only three weeks (CRP<0.5) (see FIG. 1C) and the patient was discharged with the wound into outpatient care at his own request.

It should be noted that treatment with ActiMaris Alone® was unsuccessful for more than six months, so that the infection progressed significantly with an increase in the infection parameters. After three weeks of combination therapy, the improvement in findings shown above could be achieved with normalization of the infection values.