Protocol detail

PSMA-1007 PET/CT Imaging Protocol

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Center 1, Freiburg: [¹⁸F] PSMA-1007 had been synthesized according to Cardinale et al. (11 (link)). The patients underwent a whole-body PET scan starting 2 h after injection (median activity in megaBecquerel: 313 MBq, range: 245–454 MBq). The scans were performed with a 64-slice Vereos PET/CT scanner in 61 patients and with a Gemini TF Big Bore in 23 patients (Philips Healthcare, USA). During the PET scan, a contrast-enhanced diagnostic CT scan (120 kVp, 100–400 mAs, dose modulation) was performed. The tracer uptake was quantified using standardized uptake values (SUV) normalized body weight.

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Marinescu I.M., Spohn S.K., Kiefer S., Bronsert P., Ceci L., Holzschuh J., Sigle A., Jilg C.A., Rühle A., Sprave T., Nicolay N.H., Winzer R., Rehm J., Kotzerke J., Hölscher T., Grosu A.L., Ruf J., Benndorf M, & Zamboglou C. (2022). Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients. Frontiers in Oncology, 12, 880042.

Publication 2022

Vereos PET/CT scanner Gemini TF Big Bore

Body weight Diagnostic ct scan Patients Pet ct Pet scan Psma 1007 Scans Whole body scan

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Variable analysis

independent variables

Dose of [¹⁸F] PSMA-1007 tracer (median activity in megaBecquerel: 313 MBq, range: 245–454 MBq)

dependent variables

Tracer uptake quantified using standardized uptake values (SUV) normalized body weight

control variables

Time interval between tracer injection and PET scan (2 h)
PET/CT scanners used (Vereos PET/CT scanner and Gemini TF Big Bore)
Contrast-enhanced diagnostic CT scan parameters (120 kVp, 100–400 mAs, dose modulation)

controls

No positive or negative controls were explicitly mentioned in the information provided.

Annotations

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