Participants for this study were enrolled from an ongoing prospective birth cohort in Mexico City. Between July 2007 and February 2011, we invited pregnant women receiving health insurance and prenatal care through the Mexican Social Security System (IMSS) to participate in our study. The IMSS is funded by the federal government, employers, and employees to provide health care to private-sector employees and low- to middle-class workers and their families.
To be eligible for participation in the study, women had to be <20 weeks gestation, ≥18 years old, free of heart or kidney disease, have access to a telephone, plan to reside in Mexico City for the next 3 years, not use steroids (including glucocorticoids) or anti-epilepsy drugs, and not consume alcohol on a daily basis. Institutional review boards at the Harvard School of Public Health, Icahn School of Medicine at Mount Sinai, and Mexican National Institute of Public Health. All women provided informed consent after study protocols were explained to them by research staff.
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