Cyfip2 Conditional Knockout Mouse Model

The floxed-Cyfip2 and Cyfip2^+/− mice used in this study have been previously described (Han et al., 2015 (link); Zhang et al., 2018 (link), 2019a (link); Lee S. H. et al., 2020 (link)). The CaMKIIα-Cre [B6.Cg-Tg(Camk2a-cre)T29-1Stl/J] and Thy1-YFP [B6.Cg-Tg(Thy1-YFP)HJrs/J] mice were obtained from the Jackson Laboratory. The mice were bred and maintained on a C57BL/6J background according to the Korea University College of Medicine Research Requirements. All procedures were approved by the Committee on Animal Research at Korea University College of Medicine (KOREA-2018-0174). The mice were fed ad libitum and housed under a 12 h light-dark cycle. All experiments were performed with an adult (8 to 10-week old) male Cyfip2 mice and their littermate controls.

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Zhang Y., Kang Hyae R., Lee S.H., Kim Y., Ma R., Jin C., Lim J.E., Kim S., Kang Y., Kang H., Kim S.Y., Kwon S.K., Choi S.Y, & Han K. (2020). Enhanced Prefrontal Neuronal Activity and Social Dominance Behavior in Postnatal Forebrain Excitatory Neuron-Specific Cyfip2 Knock-Out Mice. Frontiers in Molecular Neuroscience, 13, 574947.

Publication 2020

CaMKIIα-Cre [B6.Cg-Tg(Camk2a-cre)T29-1Stl/J] Thy1-YFP [ B6.Cg-Tg(Thy1-YFP)HJrs/J]

Adult Male Medicine Mice

Corresponding Organization : Seoul National University Dental Hospital

Other organizations : Korea Institute of Science & Technology Information, Korea Institute of Brain Science, Korea Institute of Science and Technology

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Variable analysis

independent variables

Genotype of mice (floxed-Cyfip2 and Cyfip2+/− mice)

dependent variables

Not explicitly mentioned

control variables

Age of mice (8 to 10-week old)
Sex of mice (male)
Genetic background (C57BL/6J)
Housing conditions (ad libitum feeding, 12 h light-dark cycle)

controls

Littermate controls

Annotations

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