A microarray dataset was retrieved from the public GEO database (www.ncbi.nlm.nih.gov/geo ); the accession number of the dataset used is GSE67567, which contains three sub-datasets: GSE67566, circRNA expression profile (platform: GPL19978, Agilent-069978 Arraystar Human CircRNA microarray V1; Agilent Technologies, Inc., Santa Clara, CA, USA) (12 (link),13 (link)); GSE63492, miRNA expression profile [platform: GPL19449, Exiqon miRCURY LNA microRNA Array, 7th generation REV-hsa, mmu & rno (miRBase v18.0); Exiqon; Qiagen, Inc., Valencia, CA, USA] (12 (link),13 (link)); and GSE56081, mRNA-lncRNA expression profile [platform: GPL15314, Arraystar Human LncRNA microarray V2.0 (Agilent_033010 Probe Name version); Agilent Technologies, Inc.] (12 (link),14 (link)). These three sub-datasets included NP samples derived from five normal control individuals and five patients with IDD.
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Integrated Transcriptome Analysis of IDD
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Other organizations : Xi'an Honghui Hospital, Xi'an Jiaotong University
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Variable analysis
independent variables
- Presence of intervertebral disc degeneration (IDD) in patients
- CircRNA expression profile
- MiRNA expression profile
- MRNA-lncRNA expression profile
- Normal control individuals
- Positive control: Samples from normal control individuals
- Negative control: Not explicitly mentioned
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