Cisplatin (Tocris, Ellisville, MO, USA) was administered intraperitoneally (i.p.) once a week at a dose of 5 mg/kg for 6 (36 days) weeks (cumulative dose: 30 mg/kg i.p.) [5 (link)]. Cisplatin was diluted in normal saline (0.9% NaCl) and delivered in a volume of 10 ml/kg body weight. Control groups were injected with an equivalent volume of saline (i.p.) in lieu of Cisplatin
[8 (link)]. Before each Cisplatin/saline i.p. injection either (1) 0.9% NaCl
[15 (link)]; (2) 4% sodium bicarbonate (NaHCO3 dissolved in 0.9% NaCl)
[8 (link)]; (3) vitamin C (25 mg/kg s.c.)
[22 (link)]; or (4) resveratrol (25 mg/kg s.c.)
[20 (link)] was administered subcutaneously in a final volume of 1 ml. Injections were always performed after completion of mechanical and cold withdrawal testing.
[8 (link)]. Before each Cisplatin/saline i.p. injection either (1) 0.9% NaCl
[15 (link)]; (2) 4% sodium bicarbonate (NaHCO3 dissolved in 0.9% NaCl)
[8 (link)]; (3) vitamin C (25 mg/kg s.c.)
[22 (link)]; or (4) resveratrol (25 mg/kg s.c.)
[20 (link)] was administered subcutaneously in a final volume of 1 ml. Injections were always performed after completion of mechanical and cold withdrawal testing.
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