Exposure to vegetation around each participant’s home address was estimated using a satellite image–based vegetation index. Chlorophyll in plants absorbs visible light (0.4–0.7 μm) for use in photosynthesis, whereas leaves reflect near-infrared light (0.7–1.1 μm). The Normalized Difference Vegetation Index (NDVI) calculates the ratio of the difference between the near-infrared region and red reflectance to the sum of these two measures and ranges from –1.0 to 1.0, with larger values indicating higher levels of vegetative density (Kriegler et al. 1969 ). For this study, we used data from the Moderate-resolution Imaging Spectroradiometer (MODIS) from NASA’s Terra satellite. MODIS provides images every 16 days at a 250-m resolution (Carroll et al. 2004 ).
We used geographic information systems (GIS) software from ArcMap (ESRI, Redlands, CA) to estimate the mean NDVI value inside radii of 250- and 1,250-m buffers around each participant’s home. We chose the 250-m radius as a measure of greenness directly accessible outside each home and the 1,250-m radius as a measure of greenness within a 10- to 15-min walk based on prior work within the Nurses’ Health Study cohorts on neighborhood environments and health behaviors (James et al. 2014 (link)). We created a seasonally time-varying measure based on the NDVI for a representative month in each season (January, April, July, and October) (Figure 1B–D). Two exposure metrics were calculated for each radius: contemporaneous NDVI (the greenness value for the current season), to reflect short-term exposure to greenness, and cumulative average NDVI (updated based on changes in seasonal NDVI as well as on changes in address), to reflect long-term exposure to greenness. For both exposure metrics, exposures were updated as NDVI changed over time as well as when participants moved to new residential addresses (updated based on the receipt of a biennial questionnaire with a new residential address).
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