Biphasic Dissolution Profiling of CorA Formulations

The dissolution experiment of neat CorA and CorA-ASD formulations were performed using the biphasic dissolution apparatus BiPHa+ [31 (link),32 (link)]. The experimental setup for the aqueous phase was identical to the monophasic setup (Section 2.4.1). Additionally, 50 mL of 1-decanol were added simultaneously to the pH shift after 20 min from pH 3.0 to pH 4.8 covering the aqueous phase [23 (link)]. The concentration profiles of both phases were measured online continuously, with an Agilent 8454 UV-Vis spectrophotometer, similar to Section 2.4.1. Figure 1 shows the experimental setup of the biphasic dissolution.

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Becker T., Krome A.K., Vahdati S., Schiefer A., Pfarr K., Ehrens A., Aden T., Grosse M., Jansen R., Alt S., Hesterkamp T., Stadler M., Hübner M.P., Kehraus S., König G.M., Hoerauf A, & Wagner K.G. (2022). In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A. Pharmaceutics, 14(8), 1657.

Publication 2022

8454 UV-Vis spectrophotometer

Corresponding Organization :

Other organizations : University of Bonn, German Center for Infection Research, University Hospital Bonn, Helmholtz Centre for Infection Research

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Variable analysis

independent variables

Formulation of CorA (neat CorA and CorA-ASD)

dependent variables

Concentration profiles of both phases (aqueous and 1-decanol) measured online continuously

control variables

Experimental setup for the aqueous phase, which was identical to the monophasic setup (Section 2.4.1)
PH shift from 3.0 to 4.8 after 20 minutes
Addition of 50 mL of 1-decanol to the aqueous phase after the pH shift

controls

No positive or negative controls were explicitly mentioned

Annotations

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