Echocardiographic Assessment of LV Function

Transthoracic echocardiograms were acquired by use of Vivid 7 or E9 (GE Healthcare) and analyzed on the EchoPAC workstation (GE Healthcare) (8 (link), 17 (link)). Left ventricular end-diastolic and end-systolic volumes were measured by the Simpson method of discs (18 (link)) in the apical 4- and 2-chamber views, and LVEF was calculated as follows: (end-diastolic volume – end-systolic volume)/enddiastolic volume × 100%. All measurements were made at a centralized reading center by a single observer who was blinded to all clinical and biomarker data.

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Putt M., Hahn V.S., Januzzi J.L., Sawaya H., Sebag I.A., Plana J.C., Picard M.H., Carver J.R., Halpern E.F., Kuter I., Passeri J., Cohen V., Banchs J., Martin R.P., Gerszten R.E., Scherrer-Crosbie M, & Ky B. (2015). Longitudinal Changes in Multiple Biomarkers Are Associated with Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab. Clinical chemistry, 61(9), 1164-1172.

Publication 2015

Vivid 7 EchoPAC workstation

Biomarker Diastolic Echocardiograms Left ventricular Systolic

Corresponding Organization :

Other organizations : University of Pennsylvania, Harvard University, McGill University, Baylor College of Medicine, The University of Texas MD Anderson Cancer Center, Piedmont Atlanta Hospital

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Left ventricular end-diastolic volume
Left ventricular end-systolic volume
Left ventricular ejection fraction (LVEF)

control variables

Transthoracic echocardiograms were acquired by use of Vivid 7 or E9 (GE Healthcare) and analyzed on the EchoPAC workstation (GE Healthcare)
All measurements were made at a centralized reading center by a single observer who was blinded to all clinical and biomarker data

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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