Newborns were scanned asleep without sedation (Laswad et al., 2009 (link)) between 1–7 weeks postpartum (median 2.8 weeks) at the Cape Universities Brain Imaging Centre (CUBIC; see Jacobson et al., 2017 (link); Warton et al., 2018 (link) for details). Scanning was performed on a 3T Allegra MRI (Siemens, Erlangen, Germany) using a circularly-polarised birdcage coil designed for use in MR imaging of neonates, which was custom-built for the study at the HST/MGH Athinoula A. Martinos Center for Biomedical Imaging (HST/MGH Martinos Center). A multi-echo FLASH (MEF) sequence (van der Kouwe et al., 2008 (link)) was acquired twice with protocol parameters: 144x144 matrix, 128 sagittal slices, TR 20 ms, TE’s 1.46/3.14/4.82/6.5/8.18/9.86/11.54/13.22 ms, 1x1x1 mm3 resolution, and flip angles 5° and 20°, respectively. Of the 52 infants scanned, 50 (27 choline, 23 placebo) provided usable data (Figure 1 ).
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Newborn Brain Imaging using Multi-Echo FLASH
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Corresponding Organization : University of Cape Town
Other organizations : Montreal Children's Hospital, McGill University, Wayne State University, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Columbia University Irving Medical Center
Top 5 similar protocols
Variable analysis
independent variables
- Choline
- Placebo
- Usable data
- Scanning performed on a 3T Allegra MRI (Siemens, Erlangen, Germany) using a circularly-polarised birdcage coil designed for use in MR imaging of neonates
- Multi-echo FLASH (MEF) sequence (van der Kouwe et al., 2008) was acquired twice with protocol parameters: 144x144 matrix, 128 sagittal slices, TR 20 ms, TE's 1.46/3.14/4.82/6.5/8.18/9.86/11.54/13.22 ms, 1x1x1 mm^3 resolution, and flip angles 5° and 20°, respectively
- Scanning was performed on newborns between 1–7 weeks postpartum (median 2.8 weeks) at the Cape Universities Brain Imaging Centre (CUBIC)
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