Example 9
CH25H was originally known to regulate cholesterol metabolism. However, when we compared the body weight, lipid deposition in liver and key enzymes involved in lipid metabolism, there was no significant change between WT and STAT1−/− mice (FIGS. 19A-19F). As shown in FIG. 19A, there was no significant difference of the body weight between APP/PS1 and APP/PS1/STAT1−/− mice. As shown in FIG. 19B, there was no significant difference in lipid deposition in liver cells between APP/PS1 and APP/PS1/STAT1−/− mice. Further, as shown in FIGS. 19C-19F, there were no significant difference of the expression of key enzymes including LPL, ABCA1, APOE, HMGCR between APP/PS1 and APP/PS1/STAT1−/− mice.