Polymetric NPs Containing JO and PTX

Polymetric NPs containing both JO and PTX (NPs/PTX-JO) and NPs lacking JO (NPs/PTX) were prepared by (low MW)-surfactant-free nanoprecipitation [28 (link)]. Different amounts of JO (1.5, 4.8, 9.6, and 19.2 μL) were dissolved in 0.8 mL acetonitrile (ACN) containing 70 μM PP and 14 μM PTX. Thereafter, ACN was added dropwise into ultrapure water (Biological Industries, Kibbutz Beit-HaEmek, Israel), and stirred at room temperature to obtain NPs with different PTX:JO molar ratios of 1:0.16 (1:1 w/w [29 (link)]),1:0.5, 1:1, and 1:2, respectively. S15-APTs were covalently conjugated to the NPs as previously described [14 (link)].

Free full text: Click here

Engelberg S., Lin Y., Assaraf Y.G, & Livney Y.D. (2021). Targeted Nanoparticles Harboring Jasmine-Oil-Entrapped Paclitaxel for Elimination of Lung Cancer Cells. International Journal of Molecular Sciences, 22(3), 1019.

Publication 2021

ultrapure water

Acetonitrile Apts Biological Molar Surfactant

Corresponding Organization : Technion – Israel Institute of Technology

Top 5 similar protocols

Variable analysis

independent variables

Amount of JO (1.5, 4.8, 9.6, and 19.2 μL) dissolved in 0.8 mL acetonitrile (ACN) containing 70 μM PP and 14 μM PTX

dependent variables

PTX:JO molar ratios of 1:0.16 (1:1 w/w), 1:0.5, 1:1, and 1:2 in the obtained NPs

control variables

Stirring at room temperature to obtain NPs
Dropwise addition of ACN into ultrapure water to obtain NPs

positive controls

NPs containing both JO and PTX (NPs/PTX-JO)

negative controls

NPs lacking JO (NPs/PTX)

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!