COVID-19 Cytokine Profiling Study

The work was approved by the Institutional Review Board (IRB) at Indiana University (#1105005445). Informed consent was obtained by all subjects. Between December 31 and October 2, 2020, 109 patients hospitalized with suspicion of COVID-19 were tested and confirmed for SARS-CoV-2 viral infection status by PCR and prospectively underwent blood collection to profile cytokines. Samples for the RT–PCR SARS-CoV-2 lab test were collected via nasopharyngeal or oropharyngeal swab at different locations, representing outpatient, urgent care, emergency and inpatient facilities. Serum specimens for Bioplex screening were collected prospectively via venipuncture within Indiana University Health. De-identified clinical and demographic data were obtained from the Indiana Network for Patient Care (INPC) research database by Regenstrief Institute. Patient electronic health records were accessed for clinical data outcomes. Clinical follow-up data were collected up to October 2, 2020, for the cohort.

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Liang S., Bao C., Yang Z., Liu S., Sun Y., Cao W., Wang T., Schwantes-An T.H., Choy J.S., Naidu S., Luo A., Yin W., Black S.M., Wang J., Ran P., Desai A.A, & Tang H. (2023). SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy. Signal Transduction and Targeted Therapy, 8, 108.

Publication 2023

Bioplex Blood Cytokines Emergency Inpatient Institutional review board Nasopharyngeal Oropharyngeal Outpatient Patient Rt pcr Sars cov 2 Sars cov 2 infection Serum Venipuncture

Corresponding Organization :

Other organizations : Guangzhou Medical University, First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Dr. Herbert & Nicole Wertheim Family Foundation, Indiana University – Purdue University Indianapolis, University of America, Catholic University of America, Northwest A&F University

Top 5 similar protocols

Variable analysis

independent variables

SARS-CoV-2 viral infection status

dependent variables

Cytokine profile

control variables

Clinical and demographic data
Patient electronic health records

controls

Positive control: None specified
Negative control: None specified

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