Polymyxin Antibiotic Pharmacokinetics and Toxicity

The recommendations in this guideline were developed following a review of studies published before December 31, 2018, in English. Studies were identified through Library of Congress, LISTA (Library, Information Science & Technology Abstracts [EBSCO]), and PubMed database searches with no date restrictions using Medical Subject Headings. Examples of keywords used to conduct literature searches were polymyxin, colistin, polymyxin B, nephrotoxicity, pharmacokinetics, pharmacodynamics, area under the curve, toxicodynamics, resistance, carbapenem, A. baumannii, P. aeruginosa, and Klebsiella pneumoniae.

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Tsuji B.T., Pogue J.M., Zavascki A.P., Paul M., Daikos G.L., Forrest A., Giacobbe D.R., Viscoli C., Giamarellou H., Karaiskos I., Kaye D., Mouton J.W., Tam V.H., Thamlikitkul V., Wunderink R.G., Li J., Nation R.L, & Kaye K.S. (2019). International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP). Pharmacotherapy, 39(1), 10-39.

Publication 2019

Carbapenem Colistin Klebsiella pneumoniae Library P aeruginosa Pharmacokinetics Polymyxin Polymyxin b

Corresponding Organization : University of Michigan–Ann Arbor

Other organizations : Detroit Medical Center, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Rambam Health Care Campus, Technion – Israel Institute of Technology, National and Kapodistrian University of Athens, University of North Carolina at Chapel Hill, Ospedale Policlinico San Martino, University of Genoa, Hygeia Hospital, Drexel University, Erasmus University Rotterdam, Erasmus MC, University of Houston, Siriraj Hospital, Mahidol University, Northwestern University, Australian Regenerative Medicine Institute, Monash University

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Variable analysis

independent variables

Polymyxin
Colistin
Polymyxin B

dependent variables

Nephrotoxicity
Pharmacokinetics
Pharmacodynamics
Area under the curve
Toxicodynamics
Resistance

control variables

Carbapenem
A. baumannii
P. aeruginosa
Klebsiella pneumoniae

Annotations

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