Effects of Psychoactive Drugs on reln-/- Mice

Buspirone hydrochloride was bought from Tocris (Cat. no. 0962), oxytocin was purchased from Sigma Aldrich (Cat. no. O3251) and risperidone was purchased from Tocris (Cat. no. 2865). Administration and concentration of the treatments were chosen according to previously published studies. Buspirone was applied by immersion in water containing 10 mg/L drug for 1 h (Bencan et al., 2009 (link)). oxytocin was applied at a concentration of 10 ng/kg by intraperitoneal injection 30 min before recording (Zimmermann et al., 2016 (link)). risperidone was applied by immersion in water containing 170 μg/L drug for 15 min (Idalencio et al., 2015 (link)). For buspirone: n = 8 WT, n = 8 reln^–/–. For oxytocin: n = 9 WT, n = 9 reln^–/–. For risperidone: n = 9 WT, n = 9 reln^–/–.