Hypofractionated IMRT for Prostate Cancer

Patient immobilization was carried out using a ProStep^TM pelvic and lower extremity support (Elekta, Stockholm, Sweden). No patient received implanted fiducials prior to radiotherapy. The clinical target volume (CTV) covered the prostate gland for low-risk tumors and also the base of the seminal vesicles for intermediate-risk cancers. The planning target volume (PTV) comprised an additional 7 mm as a setup margin. Treatment plans were generated based on the hypofractionated arm of the CHHiP trial to a total dose of 60 Gy in 20 fractions of 3 Gy (7 (link)). Dose constraints to the organs-at risk (OARs) were defined in accordance with the Quantitative Analyses of Normal Tissue Effects in the Clinic (21 (link)–23 (link)). Treatment plans for a step-and-shoot IMRT using 9 co-planar fields were generated on the RayStation planning system (RaySearch Laboratories, Stockholm, Sweden). All patients were instructed to present to each treatment fraction with a comfortably filled bladder and an empty rectum.

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Splinter M., Sachpazidis I., Bostel T., Fechter T., Zamboglou C., Thieke C., Jäkel O., Huber P.E., Debus J., Baltas D, & Nicolay N.H. (2020). Dosimetric Impact of the Positional Imaging Frequency for Hypofractionated Prostate Radiotherapy – A Voxel-by-Voxel Analysis. Frontiers in Oncology, 10, 564068.

Publication 2020

RayStation planning system

Bladder Cancers Immobilization Implanted fiducials Imrt Lower extremity Normal tissue Organs at risk Patients Pelvic Prostate gland tumors Radiotherapy Rectum Seminal vesicles

Corresponding Organization : University of Freiburg

Other organizations : University Medical Center of the Johannes Gutenberg University Mainz, Johannes Gutenberg University Mainz, LMU Klinikum, Ludwig-Maximilians-Universität München, University Hospital Heidelberg

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Variable analysis

independent variables

Patient immobilization using a ProStep™ pelvic and lower extremity support
Administration of hypofractionated radiotherapy regimen (60 Gy in 20 fractions of 3 Gy)

dependent variables

Treatment outcomes (not explicitly specified)

control variables

No patient received implanted fiducials prior to radiotherapy
Clinical target volume (CTV) coverage
Planning target volume (PTV) margin
Dose constraints to the organs-at-risk (OARs)
Treatment plans generated using step-and-shoot IMRT with 9 co-planar fields on the RayStation planning system
Patients instructed to present to each treatment fraction with a comfortably filled bladder and an empty rectum

positive controls

Not specified

negative controls

Not specified

Annotations

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