Fig. S1 shows the characterization of the IFN response of T cells to cGAMP stimulation, IFNα2a pretreatment, and Sendai virus infection. Fig. S2 shows the impact of RELA on IFN response to cGAMP in CD4+ T cells MDDCs, MDMs, and THP-1 cells. Fig. S3 shows the impact of IRF3, TSA, 5AZA, and RELA K5R on IFN response to cGAMP, viability, and signaling in CD4+ T cells. Fig. S4 shows the impact of IRF3, 5AZA, and RELA K5R on IFN response to cGAMP in CD4+ T cells. Fig. S5 shows the functional impact of iCD4+ T cells in the context of HIV infection and anti-tumor response. Table S1 provides a complete list of differentially expressed genes.