Quantifying Presynaptic Density via PET Imaging

Participants in subcohort II will undergo PET neuroimaging with [¹¹C]-UCB-J, which binds to the presynaptic vesicle glycoprotein 2A (SV2A). SV2A is ubiquitously and homogeneously located in synapses across the brain and allows for the determination of SV2A binding and presynaptic density in the brain [69 (link), 70 (link)]. However, due to the ubiquitous distribution of SV2A, there is no proper reference region in the brain, and we, therefore, measure the arterial input function. PET scanning is conducted using a High-Resolution Research Tomography (HRRT) PET scanner (CTI/Siemens, Knoxville, TN, USA). First a 6 min transmission scan, then an intravenous bolus of < 400 MBq of [¹¹C]-UCB-J administered over 20 s followed by a 90-min dynamic acquisition (256 × 256 × 207 voxels; 1.22 × 1.22 × 1.22 mm).

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Jensen K.H., Dam V.H., Ganz M., Fisher P.M., Ip C.T., Sankar A., Marstrand-Joergensen M.R., Ozenne B., Osler M., Penninx B.W., Pinborg L.H., Frokjaer V.G., Knudsen G.M, & Jørgensen M.B. (2023). Deep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort. BMC Psychiatry, 23, 151.

Publication 2023

HRRT) PET scanner

Arterial Brain Glycoprotein Scan Synapses Tomography Transmission

Corresponding Organization :

Other organizations : Copenhagen University Hospital, Rigshospitalet, Frederiksberg Hospital, Center for Clinical Research and Prevention, Vrije Universiteit Amsterdam, Amsterdam University Medical Centers

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Variable analysis

independent variables

Participants in subcohort II will undergo PET neuroimaging with [11C]-UCB-J

dependent variables

SV2A binding and presynaptic density in the brain

control variables

Arterial input function is measured due to the ubiquitous distribution of SV2A and the lack of a proper reference region in the brain
PET scanning is conducted using a High-Resolution Research Tomography (HRRT) PET scanner (CTI/Siemens, Knoxville, TN, USA)
PET scanning includes a 6 min transmission scan, followed by an intravenous bolus of < 400 MBq of [11C]-UCB-J administered over 20 s, and a 90-min dynamic acquisition (256 × 256 × 207 voxels; 1.22 × 1.22 × 1.22 mm)

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