Example 97
To a solution of N-(4-(3-cyano-4-fluorophenyl)pyridin-2-yl)cyclopropanecarboxamide (150 mg, 0.533 mmol) in 5 mL iPrOH was added RS)-3-methoxypyrrolidine (162 mg, 1.60 mmol) and DIEA (0.279 mL, 1.60 mmol) and stirred 140° C. in a microwave for 60 min. Purification by flash column chromatography gave (R)—N-(4-(3-cyano-4-(3-methoxypyrrolidin-1-yl)phenyl)pyridin-2-yl)cyclopropanecarboxamide (80 mg, 41% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 11.16 (s, 1H), 8.31-8.24 (m, 1H), 8.17 (d, J=1.7 Hz, 1H), 7.91 (d, J=2.4 Hz, 1H), 7.79 (dd, J=9.1, 2.4 Hz, 1H), 7.50 (dd, J=5.7, 1.8 Hz, 1H), 6.90 (d, J=9.2 Hz, 1H), 4.09 (td, J=4.4, 2.1 Hz, 1H), 3.77 (dd, J=11.2, 4.5 Hz, 1H), 3.67-3.57 (m, 3H), 3.26 (s, 3H), 2.16-2.01 (m, 1H), 2.05-1.94 (m, 2H), 0.89-0.79 (m, 4H). ES/MS 363.24 (M+H+).
