Genome-Wide Association Study of Vitiligo

The genome-wide portion of this study included unrelated cases from our three generalized vitiligo GWAS: GWAS1^{4 (link)} (n = 1514), GWAS2^{6 (link)} (n = 450), and the current GWAS3 (n = 1090). All cases were of non-Hispanic-Latino European-derived white ancestry (EUR) from North America and Europe, and met strict clinical criteria for generalized vitiligo⁵⁹. All controls were EUR individuals not specifically known to have any autoimmune disease or malignant melanoma, for whom genome-wide genotypes were obtained from the NCBI database of Genotypes and Phenotypes (dbGaP; phs000092.v1.p1, phs000125.v1.p1, phs000138.v2.p1, phs000142.v1.p1, phs000168.v1.p1, phs000169.v1.p1, phs000206.v3.p2, phs000237.v1.p1, phs000346.v1.p1, and phs000439.v1.p1 for GWAS1; phs000203.v1.p1, and phs000289.v2.p1 for GWAS2; phs000196.v2.p1, phs000303.v1.p1, phs000304.v1.p1, phs000368.v1.p1, phs000381.v1.p1, phs000387.v1.p1, phs000389.v1.p1, phs000395.v1.p1, phs000408.v1.p1, phs000421.v1.p1, phs000494.v1.p1, and phs000524.v1.p1 for GWAS3). Control datasets were matched to each of the three GWAS case datasets based on platforms used for genotyping. The independent replication study included 1827 unrelated EUR vitiligo cases and 2181 unrelated EUR controls not included in any of the GWAS. All subjects provided written informed consent. This study was carried out under the jurisdiction of each local IRB with overall oversight of the Colorado Multiple Institutional Review Board (COMIRB).

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Jin Y., Andersen G., Yorgov D., Ferrara T.M., Ben S., Brownson K.M., Holland P.J., Birlea S.A., Siebert J., Hartmann A., Lienert A., van Geel N., Lambert J., Luiten R.M., Wolkerstorfer A., van der Veen J.W., Bennett D.C., Taïeb A., Ezzedine K., Kemp E.H., Gawkrodger D.J., Weetman A.P., Kõks S., Prans E., Kingo K., Karelson M., Wallace M.R., McCormack W.T., Overbeck A., Moretti S., Colucci R., Picardo M., Silverberg N.B., Olsson M., Valle Y., Korobko I., Böhm M., Lim H.W., Hamzavi I., Zhou L., Mi Q.S., Fain P.R., Santorico S.A, & Spritz R.A. (2016). Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants. Nature genetics, 48(11), 1418-1424.

Publication 2016

Autoimmune disease European Genome Genotypes Gwas Hispanic Institutional review board Latino Malignant melanoma Phenotypes Replication Vitiligo

Corresponding Organization :

Other organizations : University of Colorado Denver, Universitätsklinikum Erlangen, Ghent University Hospital, University of Amsterdam, St George's, University of London, Hôpital Saint-André, University of Sheffield, University of Tartu, University of Florida, Florida College, University of Florence, San Gallicano Hospital, Columbia University, Perrigo (United States), University of Münster, Henry Ford Hospital, Colorado School of Public Health, University of Colorado Anschutz Medical Campus

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Protocol cited in 13 other protocols

Variable analysis

independent variables

None explicitly mentioned

dependent variables

Generalized vitiligo

control variables

Non-Hispanic-Latino European-derived white ancestry (EUR) individuals not specifically known to have any autoimmune disease or malignant melanoma
Matched control datasets based on genotyping platforms used for each of the three GWAS case datasets

controls

Positive control: None mentioned
Negative control: Non-Hispanic-Latino European-derived white ancestry (EUR) individuals not specifically known to have any autoimmune disease or malignant melanoma

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