No-carrier-added 177LuCl3 was obtained from Spectron MRC and PSMA-617 and PSMA-TO-1 were radiolabeled as previously described with a molar activity of 84 GBq/µmol [14 ]. Actinium-225 was supplied by the Isotope Program within the Office of Nuclear Physics in the Department of Energy’s Office of Science and radiolabeled as previously described (molar activity of 130 MBq/µmol) [13 (link)].
Radiolabeling of PSMA-Targeting Agents
No-carrier-added 177LuCl3 was obtained from Spectron MRC and PSMA-617 and PSMA-TO-1 were radiolabeled as previously described with a molar activity of 84 GBq/µmol [14 ]. Actinium-225 was supplied by the Isotope Program within the Office of Nuclear Physics in the Department of Energy’s Office of Science and radiolabeled as previously described (molar activity of 130 MBq/µmol) [13 (link)].
Corresponding Organization :
Other organizations : Molecular Theranostics (United States), University Hospital Ulm, Itasca Consultants (United States)
Variable analysis
- Labeling of PSMA-11 and PSMA-TO-1 precursors with 68Ga
- Labeling of PSMA-617 and PSMA-TO-1 with 177Lu
- Labeling of PSMA-617 and PSMA-TO-1 with 225Ac
- Yield of final 68Ga-labeled PSMA-11 and PSMA-TO-1 products (19–24 mCi)
- Molar activity of 177Lu-labeled PSMA-617 and PSMA-TO-1 (84 GBq/µmol)
- Molar activity of 225Ac-labeled PSMA-617 and PSMA-TO-1 (130 MBq/µmol)
- Amount of peptide precursors used (5 nmol for PSMA-11 and PSMA-TO-1; 10 nmol for PSMA-617)
- Previously published protocols for labeling the peptide precursors with 68Ga, 177Lu, and 225Ac
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