PSMA-11 and PSMA-617 precursors were obtained from ABX advanced biochemical compounds (Radeberg, Germany). PSMA-TO-1 precursor was obtained from Dr. H.-J. Wester (Technische Universität München, Germany). Gallium-68 was eluted from an Eckert & Ziegler IGG100 Generator and the peptide precursors (5 nmol for PSMA-11 and PSMA-TO-1; 10 nmol for PSMA-617) were labeled with 68Ga to obtain 19–24 mCi of final products according to previously published protocols [13 (link)].
No-carrier-added 177LuCl3 was obtained from Spectron MRC and PSMA-617 and PSMA-TO-1 were radiolabeled as previously described with a molar activity of 84 GBq/µmol [14 ]. Actinium-225 was supplied by the Isotope Program within the Office of Nuclear Physics in the Department of Energy’s Office of Science and radiolabeled as previously described (molar activity of 130 MBq/µmol) [13 (link)].
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