Awake GPi DBS for Parkinson's Treatment

Patients undergoing awake GPi DBS implantation surgery for the treatment of Parkinson’s disease at the University of Florida Norman Fixel Institute for Neurological Diseases were included in the study. Patients undergoing DBS implantation surgery targeted to the STN for Parkinson’s disease or the ventralis intermedius (VIM) nucleus for the treatment of essential tremor were included for comparison as controls. Informed consent was obtained for all patients for inclusion in our institutional database (Institutional Review Board #201901807). Both hemispheres were tested in a subset of patients who underwent staged bilateral DBS.

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Johnson K.A., Cagle J.N., Lopes J.L., Wong J.K., Okun M.S., Gunduz A., Shukla A.W., Hilliard J.D., Foote K.D, & de Hemptinne C. (2023). Globus pallidus internus deep brain stimulation evokes resonant neural activity in Parkinson’s disease. Brain Communications, 5(2), fcad025.

Publication 2023

Essential tremor Implantation Institutional review board Neurological diseases Nucleus ventralis intermedius Parkinson s disease Patients Surgery

Corresponding Organization : University of Florida

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Variable analysis

independent variables

Surgical target: GPi, STN, or VIM

dependent variables

Not explicitly mentioned

control variables

Parkinson's disease patients undergoing DBS implantation surgery targeted to the STN
Patients undergoing DBS implantation surgery targeted to the ventralis intermedius (VIM) nucleus for the treatment of essential tremor

controls

Positive control: Parkinson's disease patients undergoing DBS implantation surgery targeted to the STN
Negative control: Patients undergoing DBS implantation surgery targeted to the ventralis intermedius (VIM) nucleus for the treatment of essential tremor

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