Genotyping and Lactase Persistence

Genotyping was performed on the iScan System (Illumina, San Diego, CA, USA) according to the manufacturer’s recommended protocols. The quality control and imputation of rs4988235 have been described previously [7 (link)]. The LCT rs4988235 is a well-established genetic marker for non-fermented milk intake [7 (link)]. The rs4988235 genotype was categorized as CC (lactase deficiency), CT (lactase persistence), and TT (lactase persistence). Among 20,993 participants available for gene-outcome analysis, the minor allele frequency and the Hardy-Weinberg Equilibrium P value for the rs4988235 were 0.21 and 0.53, respectively.

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Zhang S., Li H., Engström G., Niu K., Qi L., Borné Y, & Sonestedt E. (2023). Milk intake, lactase persistence genotype, plasma proteins and risks of cardiovascular events in the Swedish general population. European Journal of Epidemiology, 38(2), 211-224.

Publication 2023

iScan System

Gene Genetic marker Genotype Lactase Milk

Corresponding Organization : Xi'an Jiaotong University

Other organizations : Lund University, Tianjin Medical University, Tulane University

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Variable analysis

independent variables

Rs4988235 genotype: CC (lactase deficiency), CT (lactase persistence), and TT (lactase persistence)

dependent variables

Non-fermented milk intake

control variables

The minor allele frequency and the Hardy-Weinberg Equilibrium P value for the rs4988235 were 0.21 and 0.53, respectively.

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