The Dosimetry Toolkit®, an application of the Xeleris® software provided with the SPECT/CT Discovery NM/CT 670 system (GE Healthcare) [19 ], was used to determine the radiopharmaceutical residence time in segmented organs with the multi-SPECT/CT scenario, as described by Kupitz et al. [20 (link)]. First, the application “Preparation for dosimetry toolkit” was used for SPECT/CT raw data reconstruction and CT data registration. Then, the “Dosimetry Toolkit” application was used to segment the different organs, to create the time activity curves fitted by a mono-exponential function, and to calculate the residence time.
The OLINDA/EXM® V1.0 software [21 (link)] was used to calculate the organ absorbed and effective doses. It contains a large pre-established database of radionuclides and S factors to calculate the absorbed dose per unit of administered activity. Standard or patient-adapted organ masses can be used with this software. The residence times obtained for each organ with Dosimetry Toolkit® were used as input data.
The OLINDA/EXM® V1.0 software [21 (link)] was used to calculate the organ absorbed and effective doses. It contains a large pre-established database of radionuclides and S factors to calculate the absorbed dose per unit of administered activity. Standard or patient-adapted organ masses can be used with this software. The residence times obtained for each organ with Dosimetry Toolkit® were used as input data.
Free full text: Click here
