Example 257
To a solution of tert-butyl 3-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)azetidine-1-carboxylate (190 mg, 0.426 mmol) in DCM (10 mL) were added 4 M dioxane in HCl (2 ml, 8.00 mmol), was stirred at room temperature for 3 h Concentrated the reaction mass, then the residue was washed with diethyl ether (20 mL) to afford 6-(5-(azetidin-3-yl)-3-isopropyl-1H-indol-2-yl)-8-methyl-[1,2,4]triazolo[1,5-a]pyridine (128 mg, 0.363 mmol, 85%). LCMS retention time 1.171 min. MS (E+) m/z: 346.2 (M+H).
The following Examples were prepared according to the general procedure used to prepare Example 257.
