Intraperitoneally Administered ISRIB

A single dose of ISRIB (SML0843, Sigma, St. Louis, MO, USA) at 2.5 mg kg⁻¹ (diluted in 6.25% DMSO and 6.25% PEG300) or vehicle was administered intraperitoneally 90 min prior to behavioral testing, protein analyses, or electrophysiological recordings.^{37 (link)}

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Kabir Z., Che A., Fischer D., Rice R., Rizzo B., Byrne M., Glass M., De Marco Garcia N, & Rajadhyaksha A. (2017). Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α. Molecular psychiatry, 22(8), 1096-1109.

Publication 2017

SML0843

Dmso Peg300 Protein

Corresponding Organization :

Other organizations : Cornell University, MIND Research Institute

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Variable analysis

independent variables

Administration of ISRIB (SML0843, Sigma, St. Louis, MO, USA) at 2.5 mg kg^-1 (diluted in 6.25% DMSO and 6.25% PEG300)

dependent variables

Behavioral testing
Protein analyses
Electrophysiological recordings

control variables

Administration of vehicle (6.25% DMSO and 6.25% PEG300)

controls

Positive control: Administration of ISRIB at 2.5 mg kg^-1
Negative control: Administration of vehicle (6.25% DMSO and 6.25% PEG300)

Annotations

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