Protocol detail

ARIEL3: Rucaparib for Ovarian Cancer

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Coleman R.L., Oza A.M., Lorusso D., Aghajanian C., Oaknin A., Dean A., Colombo N., Weberpals J.I., Clamp A., Scambia G., Leary A., Holloway R.W., Gancedo M.A., Fong P.C., Goh J.C., O’Malley D.M., Armstrong D.K., Garcia-Donas J., Swisher E.M., Floquet A., Konecny G.E., McNeish I.A., Scott C.L., Cameron T., Maloney L., Isaacson J., Goble S., Grace C., Harding T.C., Raponi M., Sun J., Lin K.K., Giordano H, & Ledermann J.A. (2017). Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet (London, England), 390(10106), 1949-1961.

Publication 2017

After treatment Assay Ca 125 Cancer Computed tomography Disease progression Dose reductions Eligibility Genomic Germline mutations Homologous genes recombination Mutation Ovarian Patients Placebo Radiology Rucaparib Salt Scans Symptom assessment Tissue Tumour

Corresponding Organization : The University of Texas MD Anderson Cancer Center

Other organizations : University Health Network, Princess Margaret Cancer Centre, Fondazione IRCCS Istituto Nazionale dei Tumori, Memorial Sloan Kettering Cancer Center, Vall d'Hebron Hospital Universitari, St John of God Subiaco Hospital, European Institute of Oncology, University of Milan, Ottawa Hospital, The Christie NHS Foundation Trust, National Health Service, Università Cattolica del Sacro Cuore, Inserm, Florida Hospital Cancer Institute, Centro Oncológico de Galicia, Auckland City Hospital, Royal Brisbane and Women's Hospital, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Sidney Kimmel Comprehensive Cancer Center, HM Hospitales, University of Washington, Institut Bergonié, University of California, Los Angeles, University of Glasgow, Royal Melbourne Hospital, Clovis Oncology (United States), Royal London Hospital, University College London, London Cancer, CRUK Lung Cancer Centre of Excellence

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