Evaluating Cardiac Troponin Assays Performance

To evaluate the generalizability of risk stratification thresholds we used stored samples from a substudy of the trial to compare the performance of different high-sensitivity cardiac troponin I assays (Abbott ARCHITECT_STAT and Siemens Atellica, Siemens Healthineers) and high-sensitivity cardiac troponin T (Roche Elycsys, Roche Diagnostics). Participants provided informed consent for additional blood sampling and storage, as described previously.^{20 (link)–22 (link)} The analysis population was defined in the substudy using the same inclusion and exclusion criteria as for the trial population.

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Bularga A., Lee K.K., Stewart S., Ferry A.V., Chapman A.R., Marshall L., Strachan F.E., Cruickshank A., Maguire D., Berry C., Findlay I., Shah A.S., Newby D.E., Mills N.L, & Anand A. (2019). High-Sensitivity Troponin and the Application of Risk Stratification Thresholds in Patients With Suspected Acute Coronary Syndrome. Circulation, 140(19), 1557-1568.

Publication 2019

Siemens Atellica

Assays Cardiac Diagnostics Sensitivity Troponin i Troponin t

Corresponding Organization :

Other organizations : British Heart Foundation, University of Edinburgh, Queen Elizabeth University Hospital, Glasgow Royal Infirmary, University of Glasgow, Royal Alexandra Hospital

Top 5 similar protocols

Variable analysis

independent variables

High-sensitivity cardiac troponin I assays (Abbott ARCHITECT STAT and Siemens Atellica, Siemens Healthineers)
High-sensitivity cardiac troponin T (Roche Elycsys, Roche Diagnostics)

dependent variables

Performance of different high-sensitivity cardiac troponin I and T assays

control variables

Inclusion and exclusion criteria used for the trial population

controls

Positive control: None specified
Negative control: None specified

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