APOE Genotype, Sleep and Cognition

Apolipoprotein E (APOE) genotype is expressed as a binary categorical variable, with participants classified as carriers (one or more ɛ4 alleles present) or non-carriers (no ɛ4 allele present).
As sleep may affect various aspects of cognition differently,⁴⁹ we include five cognitive composite indices, reflecting the average of domain-specific standardized test scores (Z-scores) administered as part of the WRAP battery.^{40 (link)} The cognitive composites include working memory,^{50 (link)} immediate memory, delayed memory, executive function (EF)^{51 (link)} and a Preclinical Alzheimer Cognitive Composite (PACC).^{52 (link),53} The tests contributing to each composite are shown in Supplementary Table 2.
Cognitive status is determined for each visit using a consensus review process that incorporated internal as well as published norms. A multi-disciplinary panel reviews cases to determine whether mild cognitive impairment or dementia was present.⁵⁴

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Du L., Langhough R., Hermann B.P., Jonaitis E., Betthauser T.J., Cody K.A., Mueller K., Zuelsdorff M., Chin N., Ennis G.E., Bendlin B.B., Gleason C.E., Christian B.T., Plante D.T., Chappell R, & Johnson S.C. (2023). Associations between self-reported sleep patterns and health, cognition and amyloid measures: results from the Wisconsin Registry for Alzheimer’s Prevention. Brain Communications, 5(2), fcad039.

Publication 2023

Allele Apolipoprotein e Cognitive Delayed memory Dementia Executive function Genotype Immediate memory Mild cognitive impairment Sleep

Corresponding Organization : University of Wisconsin–Madison

Other organizations : Geriatric Research Education and Clinical Center, Memorial Hospital, William S. Middleton Memorial Veterans Hospital

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Variable analysis

independent variables

APOE genotype (carriers vs. non-carriers)

dependent variables

Working memory
Immediate memory
Delayed memory
Executive function (EF)
Preclinical Alzheimer Cognitive Composite (PACC)

control variables

Cognitive status (mild cognitive impairment or dementia)

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