In 2003, the NICHD established the Stillbirth Collaborative Research Network (SCRN) to study the extent and causes of stillbirth in the United States.14 The SCRN encompasses five clinical sites, a data coordinating and analysis center, and NICHD. Stillbirth was defined as a fetal death at 20 weeks’ gestation or greater. The SCRN further defined fetal death as Apgar scores of 0 and 0 at 1 and 5 minutes with no other signs of life by direct observation. The SCRN investigators developed a prospective, multicenter, population-based case-control study of all stillbirths and a representative sample of live births occurring to residents in five geographically diverse regions. The study enrolled patients at 59 hospitals, averaging >80,000 deliveries per year, from March 2006 to August 2008. Participants underwent a standardized protocol including maternal interview, medical record abstraction, biospecimen collection, placental pathology, and, for cases, postmortem examination. General information regarding the overall SCRN study design, the development of the SCRN pathology protocols and associated data collection procedures, and the technical standards for digital photographs were previously published. In this article, we review the specific procedures for the SCRN postmortem examinations. Neuropathologic elements of the postmortem procedures are reported separately.