Biomarker Measurement in ARIC Cohort

Blood samples were taken at the time of ARIC visit 4 and plasma was stored centrally at −80°C. Hs-TnT was measured using a highly sensitive assay (Elecsys Troponin T, Roche diagnostics, Indianapolis, IN).¹⁹ NT-proBNP was measured using electrochemiluminescent immunoassay (Roche Diagnostics).^{18 (link)} Hs-CRP was assessed by immunoturbidimetric CRP-Latex high sensitivity assay from Denka Seiken using Hitachi 911 analyzer according to the manufacturer’s protocol.^{18 (link)}

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Roca G.Q., Redline S., Claggett B., Bello N., Ballantyne C.M., Solomon S.D, & Shah A.M. (2015). Sex-Specific Association of Sleep Apnea Severity with Subclinical Myocardial Injury, Ventricular Hypertrophy, and Heart Failure Risk in a Community Dwelling Cohort: The Atherosclerosis Risk in Communities-Sleep Heart Health Study. Circulation, 132(14), 1329-1337.

Publication 2015

Elecsys Troponin T CRP-Latex Hitachi 911 analyzer

Assay Blood Diagnostics Hs crp Immunoassay Immunoturbidimetric assay Latex sensitivity Nt probnp Plasma Troponin t

Corresponding Organization :

Other organizations : Pulmonary and Critical Care Associates, Columbia University Irving Medical Center, Baylor College of Medicine, Brigham and Women's Hospital

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Hs-TnT (high-sensitivity troponin T)
NT-proBNP (N-terminal pro-B-type natriuretic peptide)
Hs-CRP (high-sensitivity C-reactive protein)

control variables

Blood samples were taken at the time of ARIC visit 4
Plasma was stored centrally at −80°C

controls

No positive or negative controls were explicitly mentioned in the provided information.

Annotations

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