χ2 tests were used to evaluate associations between OR and genotype. Measures of survival were the elapsed time from date of enrollment to date of event (relapse, PD, secondary malignancy, or death) for event-free survival (EFS) and time to date of death for overall survival (OS). Log-rank tests were used to assess associations between time to event or death and genotype. For comparisons between patients who received I/T/TEMS and those who received I/T/DIN, data from all evaluable I/T/DIN patients (including those in the randomized and non-randomized cohorts) were combined. Analyses were performed using SAS (SAS/STAT User’s Guide, V.9.4; SAS Institute) and R (V.3.6.1). Survival curves were created using R (https://www.r-project.org/). As the genotypes evaluated here were associated with significant differences in clinical outcomes in previous studies,5–8 (link) a limited number of a priori hypotheses were tested and no correction for multiple comparisons was required. For genotype analyses, a p<0.05 was considered statistically significant.