Adverse Perinatal Outcomes in HIV-Positive Pregnant Women Receiving Antiretroviral Therapy

We did a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) guidelines [19 (link)]. The protocol of this review was registered in PROSPERO, the International prospective register of systematic reviews (CRD42022306896). The bibliographic research was based on both published and unpublished studies from 01/01/2002 to 29/10/2021 relative to adverse perinatal outcomes in HIV women who received antiretroviral combination during pregnancy.
Searches were conducted on four electronic scientific literature databases: PubMed, Reprotox, Clinical Trial registry (clinicaltrials.gov) and the abstracts from HIV conferences (Conference on Retroviruses and Opportunists Infections, International AIDS Society, European AIDS Clinical Society, British HIV Association and International Workshop on HIV Pediatrics). We used the keywords and MeSH terms presented in the Table 1.Table 1

Keywords and MeSH terms used in bibliographical researches

Data sources	Keywords and MeSH terms
Electronic scientific literature database (Pubmed)	("pregnancy outcome"[MeSH Terms] OR ("pregnancy"[All Fields] AND "outcome"[All Fields]) OR "pregnancy outcome"[All Fields] OR ("pregnancy"[All Fields] AND "outcomes" [All Fields]) OR "pregnancy outcomes"[All Fields]) AND ("hiv"[MeSH Terms] OR "hiv"[All Fields]) AND (antiretroviral [All Fields] OR cART [All Fields])
Electronic scientific literature databases (Reprotox, Clinical Trial registry (clinicaltrials.gov)) and abstracts from HIV conferences	“3TC, ABC, AZT, ZDV, d4T, TDF, FTC, NRTI, NNRTI, nucleoside, nucleotide, protease, DLV, EFV, ETR, NVP, APV, ATV, DRV, IDV, LPV, RTV, NFV, TPV, T-20, MVC, Atripla, lamivudine, abacavir, zidovudine, stavudine, zalcitabine, didanosine, emtricitabine, epzicom, kivexa, Trizivir, Combivir, Truvada, delavirdine, efavirenz, nevirapine, amprenavir, fosamprenavir, atazanavir darunavir, indinavir, lopinavir, ritonavir, saquinavir, tipranavir, enfurvitide, maraviroc, raltegravir, tenofovir, breast, mother, infant, baby, pregnant, pregnancy, perinatal, postnatal, feeding, breastfeeding, vertical, mtct, pmtct, “when to start” OR timing OR (“early” AND “initia*”)”