Dissociation of Tumor, Liver, and Lung Tissues
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Corresponding Organization : University of Maryland, Baltimore County
Variable analysis
- Dissociation of tumors using GentleMACS dissociator, collagenase IV, hyaluronidase, and DNase I
- Dissociation of livers using Gey's solution to lyse RBC
- Dissociation of lungs as previously described
- Obtaining single cell suspensions from tumors, livers, and lungs
- Rotation at 10 rpm and 37°C for 40 minutes during tumor dissociation
- Passing through a 70-μm mesh to remove remaining debris
- Removal of dead cells by ficoll density gradient centrifugation for some samples
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