The twice-refocused non-linear phase CPMG diffusion preparation with identical phase excitation and tipup was used for all in vivo DW-MSI acquisitions.
A 46-year-old female volunteer with two titanium screws from anterior cruciate ligament (ACL) reconstruction surgery was scanned with approval of the local Institutional Review Board and informed consent at 3T (GE Signa Premier). DW-MSI (b = 400 s/mm2) was compared to self-navigated 4-shot DW-EPI with spectral-spatial fat suppression and reconstructed with MUSE [38 (link)]. DW-MSI scan parameters are shown in Table 1. DW-EPI scan parameters were: matrix 192 × 192, voxel size 0.8 × 0.8 × 4 mm, TR = 2500 ms, TE = 62 ms, 2 NEX b=0 s/mm2, 6 NEX b=400 s/mm2. Vendor PD and Short-T1 Inversion Recovery (STIR) MAVRIC-SL were acquired for comparison.
The DW-MSI sequence was appended to clinical exams of three patients (two with unilateral hip replacements, one with bilateral intramedullary rods) following informed consent and IRB approval. These acquisitions were performed at 1.5T (GE Healthcare Optima 450W) with 30 mT/m per axis diffusion gradient amplitude and 20 T/m/s slew rate. The exam included T1-weighted and STIR MAVRIC-SL.