Standardized Tau-PET Imaging Protocol

Detailed PET scanning procedures have been described previously.^{21 (link),24 (link),25 (link)} Briefly, tau-PET scanning was performed using ¹⁸F-RO948 on a digital Discovery MI scanner (GE Healthcare). Standardized uptake value ratio (SUVR) images were created using the 70–90 min post-injection interval and the inferior cerebellar cortex as reference region.^{21 (link),22 (link),26 (link)} Each tau-PET SUVR image was rigidly co-reregistered to a high-resolution T₁- weighted MRI (Siemens3 T MAGNETOM Prisma) scan, performed a maximum of 6 months from the tau-PET scan. FreeSurfer (v.6.0, https://surfer.nmr.mgh.harvard.edu/) parcellation of the T₁-weighted MRI scan (see the 'MRI' section) was applied to the PET data to extract mean regional SUVR values that were used in region of interest analyses. We additionally obtained voxel-wise SUVRs by normalizing the MRI scans to MNI space using a standard statistical parametric mapping (SPM)12-based pipeline²⁷ and then using the deformation fields calculated for normalization of the MRI scans to MNI space to also normalize the tau-PET SUVR images.

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Groot C., Smith R., Stomrud E., Binette A.P., Leuzy A., Wuestefeld A., Wisse L.E., Palmqvist S., Mattsson-Carlgren N., Janelidze S., Strandberg O., Ossenkoppele R, & Hansson O. (2022). Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals. Brain, 146(4), 1580-1591.

Publication 2022

Discovery MI scanner

Cerebellar cortex Mri scans Pet scan Prisma Scan Scanner

Corresponding Organization : Skåne University Hospital

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Standardized uptake value ratio (SUVR) images
Mean regional SUVR values
Voxel-wise SUVRs

control variables

Time interval for SUVR image creation (70-90 min post-injection)
Inferior cerebellar cortex as reference region for SUVR calculation
Maximum of 6 months between tau-PET scan and high-resolution T1-weighted MRI scan
FreeSurfer parcellation of T1-weighted MRI scan
Normalization of MRI scans to MNI space using SPM12-based pipeline

controls

None explicitly mentioned

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