TELM Modulation of Periodontal Inflammation

Animals were treated with TELM; 10 mg/kg (Micardis^®; Boehringer Ingelheim, São Paulo, Brazil) dissolved in phosphate-buffered saline (vehicle), administered by oral gavage once daily for 15 days, beginning 1 day before PD induction. As the study main goal was to evaluate the local RAS role in the inflammation-induced bone alteration, drug treatment protocol was based on literature evidences of the anti-hypertensive effectiveness and anti-inflammatory properties in the periodontium of 10 mg/kg TELM in the rodent model (Wienen et al., 2001 (link); Araújo et al., 2013 (link)).

Free full text: Click here

Brito V.G., Patrocinio M.S., Linjardi M.C., Barreto A.E., Frasnelli S.C., Lara V., Santos C.F, & Oliveira S.H. (2020). Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Frontiers in Pharmacology, 11, 579926.

Publication 2020

Micardis

Animals Anti hypertensive Anti inflammatory Bone inflammation Drug Gavage Micardis Periodontium Phosphate Rodent Saline Treatment protocol

Corresponding Organization : Universidade Estadual Paulista (Unesp)

Other organizations : Universidade de São Paulo

Top 5 similar protocols

Variable analysis

independent variables

TELM (Micardis®; Boehringer Ingelheim, São Paulo, Brazil) administered by oral gavage once daily for 15 days, beginning 1 day before PD induction

dependent variables

Local RAS role in the inflammation-induced bone alteration

control variables

Phosphate-buffered saline (vehicle)

controls

Positive control: Literature evidence of the anti-hypertensive effectiveness and anti-inflammatory properties of 10 mg/kg TELM in the rodent model (Wienen et al., 2001; Araújo et al., 2013)
Negative control: Not explicitly mentioned

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!