Patients and 14 controls matched for TSPO affinity underwent 90-minute 11C-PBR28 MR-PET imaging on a Siemens integrated 3T MR-PET system (BrainPET), with a spatial resolution of ~2.8 mm in the center of the field of view16 (link). PET data were acquired after receiving an intravenous bolus injection of 11C-PBR28 produced in-house (mean±SD administrated dose 11.5±0.7mCi in MS versus 11.7±0.5mCi in controls, p= 0.1 by unpaired t-test), as previously described7 (link). A structural 3D-magnetization-prepared rapid scan with multiple gradient-echoes (MEMPR) images (voxel size=1mm isotropic)17 (link) was acquired simultaneously to PET data for cortical surface reconstruction, generation of attenuation correction maps18 , coregistration to PET and 7T data, and cortical thickness estimation.
Protocol detail
TSPO PET Imaging in MS Patients
Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link:
Access Free Full Text.
Corresponding Organization :
Other organizations : Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Massachusetts General Hospital, Polytechnique Montréal, Beth Israel Deaconess Medical Center
Top 5 similar protocols
Variable analysis
independent variables
- TSPO affinity
- 11C-PBR28 uptake
- MR-PET system (BrainPET) with a spatial resolution of ~2.8 mm in the center of the field of view
- Intravenous bolus injection of 11C-PBR28 produced in-house (mean±SD administrated dose 11.5±0.7mCi in MS versus 11.7±0.5mCi in controls, p= 0.1 by unpaired t-test)
- Structural 3D-magnetization-prepared rapid scan with multiple gradient-echoes (MEMPR) images (voxel size=1mm isotropic) for cortical surface reconstruction, generation of attenuation correction maps, coregistration to PET and 7T data, and cortical thickness estimation
- 14 controls matched for TSPO affinity
Annotations
Based on most similar protocols
Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.
Sign up for free or login to display all annotations
As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!