Adrenal Adenoma Diagnosis and Surgical Removal

The diagnosis of PA was performed based on the guidelines of the Japan Endocrine Society,^{9 (link)} and the details were provided in our previous report and online-only Data Supplement.^{10 (link)} Non-functioning adrenocortical adenoma (NFA) was diagnosed based on radiological findings and endocrinological results, which did not show cortisol or aldosterone elevation, also as previously reported.^{11 (link)} Unilateral laparoscopic adrenalectomy was performed to remove the APA or NFA. The diagnosis of an APA was confirmed by detecting the expression of CYP11B2 by immunohistochemistry of the resected adrenal.^{12 (link)} The clinical characteristics of the patients with APA (n = 48) and NFA (n = 13) are shown in Table S1. The genotypes of APAs were ATP1A1 mutation (n = 5), KCNJ5 mutation (n = 27), and no mutation (n = 16). Our study was approved by the ethics committee of Hiroshima University, and a written informed consent was obtained from all the patients.

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Itcho K., Oki K., Gomez-Sanchez C.E., Gomez-Sanchez E.P., Ohno H., Kobuke K., Nagano G., Yoshii Y., Baba R., Hattori N, & Yoneda M. (2019). ER chaperone calmegin is upregulated in aldosterone-producing adenoma and associates with aldosterone production. Hypertension (Dallas, Tex. : 1979), 75(2), 492-499.

Publication 2019

Adrenalectomy Adrenocortical adenoma Aldosterone Cortisol Diagnosis Endocrinological Ethics committee Genotypes Immunohistochemistry Laparoscopic Mutation Patients Radiological Supplement

Corresponding Organization :

Other organizations : Hiroshima University, University of Mississippi Medical Center, G.V. (Sonny) Montgomery VA Medical Center

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Variable analysis

independent variables

Adrenal gland pathology (APA, NFA)

dependent variables

Clinical characteristics of patients with APA and NFA
Genotypes of APAs (ATP1A1 mutation, KCNJ5 mutation, no mutation)

control variables

None explicitly mentioned

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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