Example 1
Typical flavor systems of oral care compositions (liquid peppermint flavor only) are tested against the defined organoleptic criteria defined in Table 1. Oxidized note criteria are listed in Table 2. The organoleptic properties are listed in Table 3. The quality of base coverage performance is ranked on a scale of 0 to 5 by a flavor expert.
TABLE 1
Base Coverage Scores.
Base
CoverageComments
Score5Highest organoleptic performance of base coverage,
pleasant brushing experience similar to a traditional
toothpaste, no underlying tastes of active ingredients,
solvents, polymers, etc. No lingering aftertaste.
Score4Pleasant brushing experience. No underlying tastes
of active ingredients, solvents, polymers, etc. Slight
negative lingering aftertaste from the active
ingredient.
Score3Underlying taste of active ingredients, solvents,
polymers, etc. are present during brushing. Negative
lingering aftertaste from the active ingredient.
Score2Perceivable taste of active ingredients, solvents,
polymers, etc. are present during brushing. Negative
lingering aftertaste from the formula ingredients.
Score1Minimally pleasant experience with strong taste of
active ingredients, solvents, polymers, etc. Negative
lingering aftertaste from formula ingredients.
Score0Unpleasant brushing experience, obvious and un-
pleasant tastes of active ingredients, solvents,
polymers, etc. Negative lingering aftertaste from
formula ingredients.
Quality of oxidized taste notes is ranked on a scale of 0 to 5 by a flavor expert. Oxidized taste notes are observed as flavor ingredients are oxidized over time. Oxidized flavors create unpleasant taste attributes and off-tastes in oral care formulas.
TABLE 2
Oxidized Note
Oxidized
NoteComments
Score5Extreme amount of an oxidized note, sharp, and
harsh taste that lingers
Score4High oxidized note, unacceptable
Score3Moderate oxidized note that is borderline acceptable
Score2Perceivable oxidized note that is acceptable
Score1Slight oxidized note that may not be detectable by a
non-expert
Score0No perceived oxidized note
TABLE 3
Comparison of Flavor Systems in Oral Care Formulations:
Stability
Flavoring Organoleptic Control RoomAccelerated
SystemCriteriaInitialTempAged Range
Toothpaste ABase Coverage:3.52.52
(MPS)Oxidized Notes:2.544
Toothpaste BBase Coverage:332
(4% HP)Oxidized Notes:33.54
TABLE 4
Toothpaste A Formulation.
IngredientWeight %
Potassium peroxymonosulfate0.1-5% (e.g., 1%)
Calcium pyrophosphate21-30% (e.g., 25%)
PEG/PPG triblock copolymer25-35% (e.g., 31%)
(e.g., Pluronic L35)
Polyvinylpyrrolidone1-15% (e.g., 5%)
PEG-PPG random copolymer6-15% (e.g., 10%)
Polyethylene glycol10-20% (e.g., 12.5%)
Polyphosphate2.5-5% (e.g., 4%)
Anionic Surfactant (e.g., 1-5% (e.g., 2%)
sodium lauryl sulfate)
Zwitterionic Surfactant (e.g.,0.1-1% (e.g., 0.3%)
cocamidopropyl betaine)
Fluoride source0.1 to 2% (e.g., 0.75%)
Antioxidant0 to 0.3% (e.g., 0.03%)
Thickener2.5-5% (e.g., 4%)
Totalca. 100
TABLE 5
Toothpaste B Formulation.
IngredientsWeight (%)
Humectants45-60% (e.g., 55%)
(e.g., non-crystal sorbitol, 99.5%
vegetable refined glycerin polyhydric
alcohols, polyoxyethylene glycols)
Abrasives10%-20% (e.g., 15%)
(e.g., high cleaning silica, potassium
silicate, perlite, synthetic amorphous
silica, synthetic abrasive silica,
core shell silica, precipitated silica,
precipitated calcium carbonate,
dicalcium phosphate, calcium
carbonate, sodium bicarbonate)
Thickening Agents15%-25% (e.g., 19.5)
(e.g., thickening silica, xanthan gum,
gums, carbomers, carrageenans, sodium
carboxymethyl cellulose, polyanionic
cellulose, fumed silica)
Foam Modulator1%-5% (e.g., 2%)
(e.g., sodium lauroyl sarcosinate, sodium
lauryl sulfate powder, sodium lauryl
sulfate liquid, polyethylene glycols)
Stain Prevention Agents0.5%-2.5% (e.g., 1.3%)
(e.g., tetrasodium pyrophosphate,
disodium pyrophosphate, sodium
tripolyphosphate, sodium
hexametaphosphate, zinc citrate)
Anticalculus/Anti tartar Agents0.5-2.5% (e.g., 1.30)
(e.g., stannous ion sources, poly-
carboxylate polymers, polyamino-
propane sulfonic acid, azacycloalkane-
2,2-diphosphonates, tetrasodium pyro-
phosphates, calcium pyrophosphate,
alumina, dicalcium orthophosphate
dihydrate, n-calcium pyrophosphate,
tricalcium phosphate, calcium polymeta-
phosphate, insoluble sodium
polymetaphosphate)
Anticariogenic Agents0.5%-2% (e.g., 0.8)
(e.g., fluoride ion sources, stannous ion
sources, xylitol, sodium monofluoro-
phosphate)
Hydrogen Peroxide1%-5% (e.g., 4%)
Nutrients, Colorants, Flavoring agents, q.s.
Saliva stimulating source, Desensitizing
agents, Preservatives,
Antioxidants, Water, pH Modifiers
