Longitudinal Neuroimaging of Rhesus Macaques

Thirty‐two healthy rhesus macaques used in this study were obtained from the University of Wisconsin‐Madison dataset (Young et al. 2017 (link)). Each subject has four or five longitudinal brain MRI scans (GE MR750 3.0 T) at scheduled intervals, resulting in a total of 156 scans (scanning schedule in Figure S1). The parameters of T1‐weighted MRI are as follows: TI = 450 ms, TR = 8.684 ms, TE = 3.652 ms, FOV = 140 × 140 mm², flip angle = 12 deg, thickness = 0.8 mm, gap = −0.4 mm, 80% field‐of‐view in phase encoding direction, bandwidth = 31.25 kHz, 2 averages, total time = 10:46 min, acquisition matrix = 256 × 256 and voxel size = 0.55 × 0.55 × 0.8 mm³. The parameters of diffusion MRI are as follows: TR = 8000 ms, TE = 65.7 ms, FOV = 16.7 mm, matrix = 128 × 128, slice thickness = 2.6 mm, with 1.3 mm slice overlap (resolution 1.3 × 1.3 × 2.6 mm³), up‐sampled to a voxel dimension on the scanner of 0.65 × 0.65 × 1.3 mm³, 120 gradient directions with b = 1000s/mm² and 10 images with b = 0 s/mm².