Silicone Elastomers for Dexamethasone Delivery

To prepare silicone elastomers, the MED-4735 kit from NuSil Technology was used (Carpinteria, CA, USA). The following drugs were studied: dexamethasone (three batches with similar particle sizes in the lower micrometer range, but exhibiting different polymorphic forms: Batch 1: Form A, Batches 2 and 3: blends of Forms A and B) and dexamethasone sodium phosphate (dexamethasone phosphate) (Discovery Fine Chemicals, Dorset, UK). Acetonitrile was used as a solvent (HPLC grade; Fisher Scientific, Illkirch, France). For the preparation of artificial perilymph, the following compounds were used: potassium chloride, sodium chloride, calcium chloride dihydrate, magnesium sulfate tetrahydrate and 4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid (HEPES) (HEPES Pufferan) (Carl Roth, Lauterbourg, France).

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Rongthong T., Qnouch A., Maue Gehrke M., Paccou L., Oliveira P., Danede F., Verin J., Vincent C., Willart J.F., Siepmann F, & Siepmann J. (2023). Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms. Regenerative Biomaterials, 10, rbad008.

Publication 2023

HPLC grade

Acetonitrile Calcium chloride dihydrate Dexamethasone Dexamethasone phosphate Dexamethasone sodium phosphate Drugs Ethanesulfonic acid Hepes Hplc Magnesium sulfate Perilymph Piperazine Polymorphic Potassium chloride Silicone elastomers Sodium chloride Solvent

Corresponding Organization :

Other organizations : Inserm, Université de Lille, Centre Hospitalier Universitaire de Lille, Centre National de la Recherche Scientifique

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Variable analysis

independent variables

Types of dexamethasone (three batches with similar particle sizes in the lower micrometer range, but exhibiting different polymorphic forms: Batch 1: Form A, Batches 2 and 3: blends of Forms A and B)
Dexamethasone sodium phosphate (dexamethasone phosphate)

dependent variables

Not explicitly mentioned

control variables

Silicone elastomers prepared using the MED-4735 kit from NuSil Technology
Acetonitrile used as a solvent (HPLC grade)
Artificial perilymph prepared using potassium chloride, sodium chloride, calcium chloride dihydrate, magnesium sulfate tetrahydrate and 4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid (HEPES)

controls

No positive or negative controls were explicitly mentioned in the provided information.

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